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Additional factors including patients preference and administration route must be also taken in consideration

10.1002/pmic.202200039 179 KwizeraE

The results revealed improved stability, bioactivity, and cytotoxicity against the MCF7 cell line [99]

3.2.1 Berberine clinical application and dosing In clinical trials, berberine typically is administered at 500 mg two to three times daily (11.5 g total per day)

Although it has been suggested that metformin treatment may exert a synergistic antitumor effect with ICIs, the study by Jacobi et al (107) did not obtain any positive association between metformin and ICIs in the treatment of patients with diabetes combined with NSCLC